Jay and Gloria are navigating life with their youngest son, Joe, while Manny has headed off to college to explore the world on his own terms. Meanwhile, Claire and Phil have officially lost their status as empty-nesters when Haley started her own family and moved back home with her new husband, Dylan, and a set of twins. Luke, is now looking to his next move; and Alex is learning how to balance life outside of academia. Then there's Mitchell and Cameron, who are still working to understand their gifted teenage daughter, Lily, and juggle busy careers.